About DYSPORT™ (abo-botulinum-toxin-A)

Dynamic wrinkles are caused by contractions of the delicate underlying facial muscles every time you smile, laugh or frown. The more emotion you show, the deeper these wrinkles and lines are likely to be. With passage of time your dynamic lines will slowly turn into static (permanent) lines or wrinkles. While you may have earned every one of your worry lines, you don't have to show them anymore. Now, thanks to a new use for an approved drug, dynamic lines can be dramatically softened. The procedure known as cosmetic denervation uses DYSPORT™ injections to improve the appearance of worry lines, frown lines, laugh lines, crow's feet and other dynamic wrinkles.

The active substance in DYSPORT™ is a botulinum neurotoxin type A complex, which acts at the level of the neuromuscular junction in the targeted muscle. DYSPORT™ is a neuromuscular blocking toxin which acts to block acetylcholine release at motor nerve ends and reduces muscular spasm.

Used in patient care in the United Kingdom since 1991, DYSPORT™ has marketing authorizations in 76 countries for therapeutic use and in 27 countries for aesthetic use. Patient exposure is estimated to be above two million single treatment cycles, representing more than 600,000 patients year of treatment.

DYSPORT™ was initially developed and subsequently approved in many markets around the world, outside the U.S., for the treatment of movement disorders such as cervical dystonia (spasmodic torticollis), blepharospasm (involuntary eye closure), hemifacial spasm and various forms of muscle spasticity, including post-stroke arm spasticity, spasticity of the lower limbs (calf) in adults and children with cerebral palsy. It was later developed for the treatment of a wide variety of neuromuscular disorders and aesthetic medicine.